Colloidal Silver-Versus Ionic Silver

"One of the most frequently asked questions I get is "What's the difference between true colloidal silver, nanosilver and ionic silver?"

This question is largely spurred by websites promoting the erroneous idea that there's only one kind of colloidal silver – which they refer to as "true colloidal silver" – and that all other forms of colloidal silver are somehow inferior to it in antimicrobial effectiveness.

Of course, nothing could be further from the truth. And I'll document that for you step-by-step, directly below. Here are the basic scientific facts the purveyors of "true colloidal silver" don't want you to know...

To understand the differences between so-called "true colloidal silver," nanosilver and ionic silver you first have to grasp the simple fact that the term "colloidal silver" is an umbrella term covering many different types of liquid antimicrobial silver products, such as:

Ionic silver – extremely small, positively charged atoms or molecules of silver in a colloidal suspension

Metallic silver – bare metal silver particles averaging 100 nm or larger, in a colloidal suspension

 Nanosilver – bare metal silver particles averaging less than 100 nm in size, in a colloidal suspension

Mild Silver Protein – bare metal particles of silver complexed with denatured protein such as casein, in a colloidal suspension

Silver Citrate – ionic silver complexed with citric acid, in a colloidal suspension

While there are some pretty big differences between each of these forms of colloidal silver, the main thing to remember is that they're all "colloidal" in nature.

That is to say, they're all composed of relatively small particles of one form of silver or another, suspended homogenously and indefinitely in water. They're not dissolved in the water. They're tiny, submicroscopic particles of silver suspended in the water.

What makes each of these forms of colloidal silver different is how they're produced and how they work inside the human body.

So in the remainder of this article we're going to examine those two crucial factors carefully. But for the sake of time, we're only going to look at the two most popular forms of colloidal silver, i.e., the ionic form and the metallic form.

The Differences Between Ionic Silver and Metallic Silver

The two main types of colloidal silver vying for the spotlight today are the ionic form, and the metallic form. And it's around these two forms of colloidal silver that most of the controversy swirls. So we'll take a good hard look at the differences between these two forms of colloidal silver, below.

The ionic form of colloidal silver is the most common form sold in health food stores today.

Indeed, it's been the #1 best-selling form of colloidal silver for over 100 years, and it continues to be the bestselling form of colloidal silver to this very day.

The metallic form of colloidal silver is the second most common form sold in health food stores today. It can also be referred to as nanoparticle silver, but only if the metallic silver particles it's composed of are less than 100 nm in size on average.

Metallic Silver Facts

Let's examine the metallic form of colloidal silver first:

This form of colloidal silver is also often erroneously referred to by internet marketers as "true colloidal silver".

It's important to note, however, that the term "true colloidal silver" is a completely made-up term. It cannot be found anywhere in the scientific or medical nomenclature. That's because it's an advertising gimmick, and not an actual recognized medical or scientific term.

In fact, a friend of mine who's been the research director of a pharmaceutical firm for years often challenges people to find the term "true colloidal silver" in any reputable medical textbook or clinical reference work. He even offers to buy them a gallon of their favorite brand of "true colloidal silver" if they can produce such a reference.

 But he's never been taken up on the challenge because there's simply no reference to "true colloidal silver" in any of the standard recognized medical or clinical reference texts in the entire world.

In short, there's simply no such thing as "true colloidal silver". Clinical researchers won't even use the term in their clinical studies because they don't want to be laughed out of the room.

So for the sake of clarity and scientific accuracy we'll continue to use the correct nomenclature and refer to the so-called "true colloidal silver" as the metallic form of colloidal silver, or nanosilver.

The metallic form of colloidal silver is generally manufactured through a chemical process in which a silver compound such as silver nitrate or silver acetate is chemically reduced until there's nothing left but tiny, bare metal particles of elemental silver suspended in water.

But metallic silver can also be manufactured through a high-voltage A/C process in which extremely high voltages of electricity up to 25,000 volts are used to force tiny particles of elemental silver to disassociate (i.e., break loose) into water from a larger silver rod or bar.

Another less-often-used method for producing the metallic form of colloidal silver is to take finely ground-up elemental silver and add it to water while sonicating it (i.e., mechanically agitating the silver particles) in order to bring it into a colloidal suspension.

The bottom line is that no matter how you produce the metallic form of colloidal silver, when you drink it you're drinking tiny particles of bare metal elemental silver. It would be the same as if you could use your knife to whittle raw silver particles off a silver coin, only the silver metal particles in the metallic form of colloidal silver are much smaller, of course.

Ionic Silver Facts

Now let's examine the ionic form of colloidal silver:

 The ionic form of colloidal silver is almost always produced through a low-voltage D/C electrical process, rather than being chemically manufactured, ground up and mechanically sonicated or disassociated with from elemental silver using high-voltages of electricity.

What happens is that a current of low-voltage electricity is passed through two pure silver rods immersed in pure distilled water. As the electrical current passes through one of the silver rods, hydrogen and hydroxide ions are produced making the distilled water slightly conductive – just enough to allow the electrical current to flow through the water toward the other silver rod.

As this process gradually accelerates, submicroscopic silver ions (i.e., tiny atomic and molecular particles of pure silver) are slowly liberated into the water from one of the silver rods, where they're suspended by a positive electrical charge. 

These tiny atomic and molecular particles of silver act as electrolytes, allowing the electrical current to flow even more strongly between the two silver rods, liberating even more silver ions in the process.

Unlike the metallic form of colloidal silver, these are not tiny particles of bare metal elemental silver. Instead, they're tiny, electrically-charged atomic and molecular particles of silver – which is to say, they're silver particles missing an electron.

Physically, the missing electron and the resulting positive electrical charge is the only thing that distinguishes these silver particles from bare metal elemental silver particles.

Indeed, it's that missing electron that allows the tiny silver ions to carry their positive electrical charge, which does two things:

1) Makes the silver far more biologically active inside the human body against pathogens, and...

2) Makes the silver and far more bio-available (i.e., easier for the body to absorb and utilize).

I'll explain why this is true, in-depth, throughout the remainder of this article. But simply put, the ionic form of colloidal silver is the most readily bio-available and bio-effective form, which is exactly why it's been the #1 best-selling form of colloidal silver for nearly 100 years.

You may not realize it, but the ionic form of colloidal silver is the same naturally occurring form of silver found in food plants such as wheat, edible mushrooms, edible sea vegetables (Nori, Kombu, Wakame, Arame, Hijiki, Dulse) and others.

You see, plants absorb minerals from the ground or from the water through their root systems or other nutrient intake systems. And they quickly convert these minerals into their ionic form. 

Why?

Because it's the ionic form that's the most readily bio-available...the most biologically active...and therefore the most useful and beneficial in the body for both humans and animals that eat the plants.

So Mother Nature makes sure that minerals are in their most bioavailable form in our food plants, so we'll get the most out of them, nutritionally speaking, when we eat them.

Were this not true, there would be little positive benefit whatsoever from eating plants in order to obtain the minerals our bodies need to function. We could just eat dirt instead, and consume our minerals in their elemental (i.e., metallic) form. But the human body is simply not equipped to use the elemental form of silver very well.

Instead, nature has decreed that the human body utilizes minerals – including silver – in the ionic form, which, again, is exactly why Mother Nature has her food plants convert minerals into the ionic form.

So when you use the ionic form of colloidal silver, you're using the same form that occurs naturally in food plants. In other words, minerals in their ionic form are the way Mother Nature intended for them to be ingested.

A Brief Review

To briefly review, when you ingest the metallic form of colloidal silver (i.e., nanosilver, or so-called "true colloidal silver"), you're ingesting tiny, bare metal elemental silver particles in a colloidal suspension.

And when you ingest the ionic form of colloidal silver, you're ingesting tiny, submicroscopic atoms and molecules of silver – also known as ionic silver particles – that have been electrically liberated from bare metal silver into a colloidal suspension.

In spite of what's been said on the internet, both metallic silver suspensions and ionic silver suspensions are "colloidal silver". After all, they're both composed of tiny particles of silver suspended homogeneously and indefinitely in a liquid solution.

The big difference between the two is that the metallic form of colloidal silver is composed of tiny, bare metal particles of elemental silver, while the ionic form of colloidal silver is composed of tiny positively-charged atomic or molecular particles of silver that have been liberated from metallic silver using low-voltage electricity. 

Both are "colloids", with the bare metal elemental silver suspension being a metallic colloid, and the ionic silver suspension being a colloidal electrolyte (due to the electrically charged atomic and molecular particles of silver).

This is why both forms – metallic and ionic – have been universally called "colloidal silver" for the past 100-plus years, until only recently when purveyors of the metallic form began claiming only theirs could be called a "true colloid". It's a great marketing gimmick. But scientifically speaking, the claim is a farce.

The metallic silver suspensions are colloids. And the ionic silver suspensions are colloids.

Again, one is a colloidal suspension of tiny metal particles of silver. And one is a colloidal suspension of tiny electrically-charged ionic particles of silver just like you’d find naturally in edible plants. 

The Truly Important Distinction

Now here's the truly important distinction you need to understand:

It's the tiny, submicroscopic silver ions (i.e., positively charged atoms or molecules of silver) that give ALL forms of colloidal silver their infection-fighting properties.

In fact, ALL reputable experts agree that silver ions are the biologically active, infection-fighting "specie" of silver, while bare metal elemental silver particles have almost no infection-fighting qualities of their own except to the extent that they shed silver ions when they come into contact with acidic bodily fluids or highly-oxygenated body tissues.

For example, here's a quote from Britain's top expert on antimicrobial silver, Alan B.G. Lansdown, author of Silver In Healthcare: Its Antimicrobial Efficacy and Safety in Use, which is considered to be the definitive textbook for doctors on the medical use of silver: 

"Metallic silver is inert in the presence of human tissues but ionizes in the presence of moisture, body fluids, and secretions to release the biologically active Ag+".

– Alan B.G. Lansdown,

A Pharmacological and Toxicological Profile of Silver as an Antimicrobial Agent in Medical Devices, Advances in Pharmacological Sciences, Vol. 2010, Article ID 910686

As you can see, Dr. Lansdown agrees that the silver ion (also known as Ag+) is the biologically active, infection-fighting form of silver, and that metallic silver is basically inert except to the extent it begins to shed silver ions in the body when it comes into contact with certain bodily fluids.

Here's another quote; this one from Microbe Wiki, the online encyclopedia of all things microbial:

"In order for silver to have any antimicrobial properties, it must be in its ionized form. Silver in its non-ionized form is inert, but contact with moisture leads to the release of silver ions."

– Microbe Wiki, Silver As An Antimicrobial Agent

That's pretty darned clear, I think you'll agree. Silver must be in the ionized (i.e., ionic) form in order to kill pathogens.

If silver is in its non-ionized form (i.e., metallic elemental silver) it can only kill pathogens to the extent it begins to shed silver ions when it comes into contact with acidic bodily fluids. This simple fact is recognized throughout both science and industry. For example, here's another quote, this one from an industry source:

"Metallic silver is relatively unreactive. However, when exposed to aqueous environments some ionic silver (Ag+) is released...

...the principle activity of silver is as a result of the production of silver ions within an aqueous matrix."

– Technical White Paper: Antimicrobial Activity of Silver, Industrial Microbiological Services Ltd., September 2005

And here's another expert quote, this one from top Rice University researchers who have studied the question of metallic versus ionic silver extensively:

"Scientists have long known that silver ions, which flow from nanoparticles when oxidized [i.e., when they lose an electron – ED] are deadly to bacteria.

But scientists have also suspected silver nanoparticles themselves may be toxic to bacteria, particularly the smallest of them at about 3 nanometers.

Not so, according to the Rice team that reported its results this month in the American Chemical Society journal Nano Letters.

In fact, when the possibility of ionization is taken away from silver, the nanoparticles are practically benign in the presence of microbes."

– Rice University News, "Ions, Not Particles, Make Silver Toxic to Bacteria", quoting Pedro Alvarez, George R. Brown Professor and chair of Rice's Civil and Environmental Engineering Department

And quoting directly from the Abstract of the actual Rice University study, titled "Negligible Particle-Specific Antibacterial Activity of Silver Nanoparticles", which was published in the July 5, 2012 issue of the journal Nano Letters:

"For nearly a decade, researchers have debated the mechanisms by which AgNPs [i.e., silver nanoparticles] exert toxicity to bacteria and other organisms.

The most elusive question has been whether the AgNPs exert direct "particle-specific" effects beyond the known antimicrobial activity of released silver ions (Ag+).

Here, we infer that Ag+ [i.e, silver ions – ED] is the definitive molecular toxicant.

We rule out direct particle-specific biological effects by showing the lack of toxicity of AgNPs [i.e., metallic silver – ED] when synthesized and tested under strictly anaerobic conditions that preclude Ag(0) oxidation and Ag+ release.

In other words, when the researchers took away the ability of the metallic nanosilver to shed silver ions, the metal particles were no longer toxic to bacteria. It is only when metallic silver (i.e., nanosilver) is able to shed silver ions that it can kill bacteria.

Again, that's brand new research by top clinical researchers from Rice University. But it's been known for over half a century that metallic silver is biologically inert – meaning it has no antimicrobial qualities of its own except to the extent it sheds biologically active silver ions.

But it's backed up by tons of previous research. In January 2009, in the journal Quanta, researcher S.M. Foran wrote in an article titled "Therapeutic Properties of Silver: An Historical and Technical Review":

"Neutral silver [i.e., metallic silver – ED] does not have the microcidal nature that silver does in the ionic state. The charge of the ion is necessary in facilitating electron displacement in microbes...

...Reduced or neutral silver [i.e., metallic silver – ED] have no known medical value. These include silver salts, silver compounds and colloids that are created without ions...

...These produces will still provide some benefits if there are silver ions present, but most of them have difficulty achieving biologically meaning concentrations of Ag+"

And in their technical white paper "Everything You Ever Wanted to Know About the Use of Silver in Wound Therapy", Systagenix Wound Management (one of the world's largest providers of wound care products for hospitals and doctors) wrote:

"Silver can exist in 'elemental' or 'ionic' form. Silver ions are also referred to as 'Ag+' or 'silver cations'.

All silver-containing products, whether elemental or ionic, achieve their antimicrobial effect via the action of silver cations (i.e., silver ions)."

In other words, the silver can be in the elemental metal state, or it can be in the ionic state, but there's no way for it to kill pathogens except in the ionic state. The elemental metal form has to convert to the ionic form in order to work. It has to shed silver ions in the presence of pathogens, or it's otherwise benign.

If you'd like to learn more about this critical point, take a moment to read my extensively-documented article, "Experts: It's the Silver Ion that Gives Colloidal Silver Its Antimicrobial Power".

In that article, you'll find dozens of quotes from bona-fide clinical research and medical experts going back half a century or more and documenting the fact that the silver ion (i.e., ionic silver) is the biologically active, infection-fighting "specie" of silver, and that metallic (or elemental) silver, even in its nanoparticle form is biologically inert against pathogens except to the extent it sheds silver ions.

So here's the key to understanding the controversy over the ionic form of colloidal silver versus the metallic form of colloidal silver (which is erroneously referred to as "true colloidal silver"):

When you ingest the metallic form of colloidal silver, in order for these tiny particles of bare metal elemental silver to be effective in the human body they must first be converted by the body into the ionic form of silver.

In other words, they have to shed silver ions. They do this when they come into contact with acidic bodily fluids or highly-oxygenated tissues. This, in turn causes the metal particles to liberate silver ions into the surrounding area. It's a far slower and less effective process than simply ingesting silver ions.

In other words, for the metallic form of colloidal silver to work, it has to be broken down and converted inside of your body into the ionic form of silver, i.e., into those tiny components of silver we call silver ions.

But when you ingest the electrically-generated ionic form of colloidal silver, there's no conversion process needed. Your body does not need to break it down any further, because it's ALREADY in the biologically active, infection-fighting form – the same naturally bio-available form you'll find it in, in plants.

With the ionic form of colloidal silver, you're ingesting tiny, submicroscopic, electrically-charged atoms and molecules of silver, called silver ions. Silver ions are the "bioactive" form of silver that are so useful in the human body because they're so deadly to pathogens.

Which One Works?

The bottom line is this: Technically speaking, either form of colloidal silver – ionic or metallic – work. Both have powerful antimicrobial qualities.

But...in order for the metallic form of colloidal silver to kill pathogens it has to undergo a gradual conversion process inside the human body. It has to come into contact with acidic bodily fluids or highly oxygenated tissues and then start shedding silver ions, which are what actually kill the bacteria.

On the other hand, when you ingest the electrically-generated ionic form of colloidal silver no conversion is necessary. It's ready to work immediately because it's already in the biologically active, infection-fighting state.

In short, both of them work just fine.

But the metallic form (i.e., the so-called "true colloidal silver") works much slower, and far less efficiently, because the tiny bare metal particles it's composed of are inert (i.e., have no antimicrobial activity on their own) and have to undergo that gradual conversion into silver ions inside the human body before they can even begin to work against pathogens.

For further documentation, see this article from Rice University researchers demonstrating that the metallic (i.e., nanoparticle) form of silver is biologically inert, and cannot kill pathogens unless it sheds biologically active silver ions.

Electrical Charges

As long as we're delving this deeply into the science behind colloidal silver, I suppose I could also explain that ionic silver works best against pathogens because it carries a positive electrical charge, while metallic silver (or nanosilver) carries no electrical charge at all.

This is very important to understand. In science, it's well known that like electrical charges repel each other, and opposite electrical charges attract each other.

And since bacteria tend to carry a negative electrical charge on their cell wall, positively-charged silver ions have a strong affinity for them.

You see gram positive bacteria carry a negative electrical charge on their cell walls thanks to the presence of teichoic acids linked to either the eptidoglycan or to the underlying plasma membrane. These teichoic acids are negatively charged because of presence of phosphate in their structure.

And gram negative bacteria have an outer covering of phospholipids and lipopolysaccharides, with the lipopolysaccharides imparting a strongly negative charge to the surface of the bacterial cell wall.

So thanks to the positive electrical charge on silver ions, a very strong affinity exists between them and gram positive and gram negative forms of bacteria. In short, the silver ions are strongly attracted to bacteria. But metallic silver does not carry this same electrical attraction, because it does not carry an electrical charge.

The bottom line, as Albert T. McManus, M.D., Chief of Microbiology, Institute of Surgical Research at Fort Sam Houston Army Burn Center in Houston, Texas has observed:

"...conversion of metallic silver to silver ions is necessary for efficacy" and "the silver ion will react with any negative charge presented by a pathogen's transport or membrane proteins and deactivate them."

In short, because silver ions are missing an electron, they're positively charged, which causes them to be attracted to the cell wall of the pathogens at which point they then begin to destabilize the cell wall and disrupt cellular metabolism of the pathogen.

As clinical researcher Eric Rentz states in his retrospective study of silver, published in the Journal of Nutritional & Environmental Medicine:

Microbial cells "selectively bond only with Ag+ [i.e., ionic silver – ED]."

And as researcher S.M. Foran wrote in an article titled "Therapeutic Properties of Silver: An Historical and Technical Review", which was published in the January 2009 issue of the journal Quanta:

"Neutral silver [i.e., metallic silver – ED] does not have the microcidal nature that silver does in the ionic state. The charge of the ion is necessary in facilitating electron displacement in microbes..."

So again, it's the SILVER ION that gives silver all of its infection-fighting properties. And it's largely the positive electrical charge held by the silver ion that makes silver's biocidal properties possible.

Metallic silver does not carry this crucial positive electrical charge. So it does not seek out, bind to and destroy pathogens like ionic silver does. It can only destroy pathogens to the extent that it converts to the ionic form of silver in the human body, which generally happens on a very gradual basis in the presence of acidic bodily fluids or highly oxygenated tissues – a much slower and less effective process. Never let anyone tell you differently.

Now You Know...

Now you know why the ionic form of colloidal silver has been the world's #1 best-selling form of colloidal silver for over 60 years.

The ionic form of colloidal silver sells better, because it works faster and more efficiently in the human body than the metallic form (i.e., nanosilver, or so-called "true colloidal silver") which is composed of nothing but tiny bare particles of elemental silver metal that cannot even begin to kill microbes until they start shedding silver ions.

So the question of the day is this:

Why even bother to ingest a colloidal silver solution consisting of bare metal silver particles that need to be converted into silver ions inside the human body, when instead you can ingest a colloidal silver solution consisting of pure silver ions that need no conversion at all?

Stomach Acid Nonsense

Now, of course, the purveyors of the metallic form of colloidal silver will tell you that the ionic form of colloidal silver simply doesn’t work against pathogens in the human body.

They claim – erroneously, of course – that this is because silver ions easily get tied-up in the gut by hydrochloric acid (i.e., stomach acid) and are thereby converted to silver chloride and neutralized.

And they claim that only their metallic form of colloidal silver can possibly work inside the human body, because it doesn’t get tied-up in the gut by stomach acid, but instead is absorbed through the gastrointestinal barrier and ends up in the blood where it's carried into the body's cells, tissues and organs.

But if that little bit of marketing claptrap were true, then the metallic form of colloidal silver – the so-called "true colloidal silver" – could not possibly work either. 

After all, as I've demonstrated repeatedly in this article, for the metallic form of colloidal silver to work in the body, pathogen-killing silver ions must be liberated from the bare metal silver particles.

And that conversion from metallic silver to ionic silver can only take place in the presence of acidic bodily fluids or highly-oxygenated tissues.

Of course, stomach acid is highly acidic. That's why they call it stomach acid. So, metallic silver begins shedding silver ions as soon as it comes into contact with stomach acid.

But if ionic silver is tied-up and neutralized in the gut by hydrochloric acid, then the silver ions being shed by metallic

silver particles inside the stomach would also become tied-up and neutralized by stomach acid.

And in such a case, neither form of colloidal silver could possibly kill pathogens inside the human body, because it's the silver ion that's the biologically active, infection-fighting "specie" of silver. The silver ion, and only the silver ion, kills pathogens.

So the purveyors of the metallic form of colloidal silver shoot themselves in the foot every time they make the claim that silver ions get tied up in the gut by stomach acid and are thereby turned into silver chloride and neutralized.

Again, if this were true the effectiveness of their own product would be equally neutralized once ingested, since it begins shedding silver ions in the gut in reaction to stomach acid, and indeed, is completely dependent upon shedding silver ions in order to work against pathogens.

“Well, Steve," you might say, "what if the metal particles are absorbed across the gastrointestinal barrier and into the bloodstream, and only then begin to shed silver ions?"

Interesting question. Aside from the fact that it physically can't happen that way due to the hydrochloric acid in the stomach which starts the process of liberating silver ions from the metallic silver in earnest, there's another problem, as well. Here it is:

The "true colloidal silver" people make the following claim on their own website: "If some ionic silver were ever able to get into the bloodstream it would encounter a large supply of chloride ions owing to the fact that the blood serum is rich in sodium and potassium chloride, again, quickly forming silver chloride."

So if that's true, then metallic silver particles releasing silver ions in the bloodstream would also have their effectiveness completely neutralized, because the released silver ions would be neutralized as they formed silver chloride.

 Do you see how the "true colloidal silver" people continue to shoot themselves in the foot over and over and over again with their spurious claims?

 In just a moment, I'll show you exactly how silver ions manage to get through the harsh chemical environment of the gastrointestinal tract, and the bloodstream, and make it into the cells, tissues and organs of the human body where they can work their magic against pathogens.

But first, here's a big surprise for you:

A Big Surprise...

While the so-called "true colloidal silver" people continue to make the claim that ionic silver gets tied-up in the gut and neutralized by hydrochloric acid, recent clinical research demonstrates that it's actually their metallic form of colloidal silver that gets tied-up in the gut and neutralized by hydrochloric acid.

In fact, this has been demonstrated clinically, time and time again, most recently by researchers from the University of Nevada in cooperation with scientists from the EPA's Office of Research and Development.

In their clinical study, these researchers "exposed silver nanoparticles to synthetic human stomach fluid to see how ingested nanoparticles could be altered by the stomach's very acidic environment."

According to the researchers: 

"A variety of analytical methods showed that nanoparticles formed large aggregates and produced silver chloride when exposed to stomach fluid. 

Changes in nanoparticle physical form and surface chemistry that occur in the stomach may affect how much silver will be absorbed across the gastrointestinal barrier."

In short, the researchers discovered that metallic silver nanoparticles (i.e., nanosilver, or so-called "true colloidal silver") formed large clumps and began converting to silver chloride when exposed to stomach acids.

The researchers surmised that because of this, the human body would likely have significant trouble absorbing and utilizing metallic nanosilver particles.

Of course, that's just the opposite of what the "true colloidal silver" people will tell you. They claim that metallic silver will not interact with stomach fluids, and that therefore it's easily absorbable into the body from the gastrointestinal tract. 

They further claim that it's the ionic form of colloidal silver that gets tied up in the gut and cannot make past the gastrointestinal barrier. But the only evidence they produce for their claims is from their own in-house lab.

No independent clinical research backs up their claims. Quite the opposite, in fact – most truly independent clinical research destroys their claims. 

Even the infamous Brown University clinical study on argyria, conducted in August 2012, found that metallic nanosilver was "not terribly likely to make it from the GI tract to the blood..." but that silver ions shed by the metal nanosilver in reaction to the acidic environment of the stomach were "easily absorbed into the bloodstream". Again, that's the exact opposite of what the purveyors of "true colloidal silver" claim.

Indeed, the Brown University researchers found that:

"...nanosilver corrodes in stomach acid in much the same way it does in other acidic environments.

Corrosion strips silver atoms of electrons, forming positively charged silver salt ions. Those ions can easily be taken into the bloodstream..."

So in light of these studies and others like them, it would seem that the purveyors of the metallic nanosilver products which they erroneously call "true colloidal silver" are either ignorant of the actual science, or not always completely honest with their customers.

That's probably a gross understatement.

The Problem With Simulated Studies

 Nevertheless, while the above two studies are fascinating because they further document the fact that metallic nanosilver by itself is basically worthless except to the extent that it sheds silver ions in the body, both studies were nevertheless based upon simulated body systems, i.e., they used simulated stomach acid, simulated blood, simulated tissues, simulated skin, etc.

And in such clinical simulations, no matter how close these researchers can come to the real thing, they still can't reproduce the dynamic biological milieu of the human body, with all of its chemical complexities.

I say this for a very specific reason.

After all, in spite of the simulation studies, it's abundantly clear from real-life experience as well as from clinical experience that both forms of colloidal silver – the ionic form and the metallic form – work effectively against pathogens inside the human body.

So please don't think I'm trying to say that metallic silver doesn't work. I'm not. I'm just demonstrating that their claims against ionic silver are based on fantasy, deception or gross misunderstanding of the colloidal science.

Indeed, there's tons of clinical documentation for the effectiveness of the metallic form of colloidal silver. And there's tons more clinical documentation for the effectiveness of the ionic form of colloidal silver.

There's also thousands upon thousands of real-life human and animal anecdotal accounts demonstrating the effectiveness of both forms of colloidal silver.

What's more, this broad spectrum of evidence for the effectiveness of both forms of colloidal silver stretch back over a period of more than 100 years. So how can this be?

 How can both forms of colloidal silver work against pathogens in the human body if metallic silver gets corroded by stomach acid, forming clumps and turning into silver chloride (as the University of Nevada and Brown University clinical studies clearly demonstrate), and if ionic silver gets turned into silver chloride in the stomach and is neutralized (as the purveyors of the metallic form of colloidal silver claim)?

Thankfully, there's a very simple, often overlooked answer...

The Metalloprotein Transport System:

 The Final Piece of the Puzzle

Both forms of colloidal silver – the metallic silver form and the ionic silver form – demonstrate broad-spectrum antimicrobial activity in the human body for one reason, and one reason only:

It's because the human body has a very effective transport mechanism for safely escorting silver ions through the harsh acidic chemical environments encountered inside the human body and into the cells, tissues and organs where they can work against pathogens that colonize and cause illness and disease.

And it's this transport mechanism – known as the Metalloprotein Transport System – the clinical researchers simply can't duplicate in their simulated studies.

I've written about the Metalloprotein Transport System many times. So if you'd like, you can read more extensively about it in my article titled "Metalloproteins – the Body's Transport Mechanism for Ionic Silver".

The upshot of the matter is this: Without the Metalloprotein Transport System, neither the ionic form of colloidal silver nor the metallic form of colloidal silver could possibly work inside the human body.

After all, the ionic form of colloidal silver is composed largely of pure silver ions. And the metallic form of colloidal silver is completely dependent upon conversion to silver ions inside the body in order to demonstrate any antimicrobial activity whatsoever.

So both forms would ultimately be neutralized by acids or chloride ions not just in the stomach, but elsewhere in the body as well.

 But substances called metalloproteins protectively bond with silver ions and then escort them through the harsh chemical environment of the gastrointestinal tract and into the bloodstream where they’re carried safely into the cells, tissues and organs of the human body before being released to work their magic against pathogens.

And that's why both form of colloidal silver work well in the human body.

 You see, metalloproteins are produced inside the human body in direct response to the presence of metallic ions. This is true for silver ions, zinc ions, copper ions or any other metallic mineral ion.

So when you ingest ionic silver, your body will immediately begin to produce metalloproteins such as metallothionein to escort those silver ions through the harsh chemical environment of the stomach, and into the deeper reaches of the body.

And when you ingest metallic silver, the same things happens, but far more slowly. As the metallic silver particles come into contact with acidic bodily fluids beginning in the GI tract, these metal particles begin shedding silver ions, just as the above studies have documented.

And it's at that point the body will start producing the metalloproteins needed to escort those silver ions through that harsh chemical environment and into the bloodstream, organs, tissues and cells of the body where pathogens colonize.

Researchers can't simulate that in a study, because it's too difficult to simulate the rich biochemical milieu of the human body in its entirety.

They can't coax a simulated body system – with simulated blood, simulated stomach acid, simulated tissues and simulated skin – to produce metalloproteins in response to the presence of silver ions.

But the human body, of course, is quite capable of doing so. It's not a simulated system. It's the real deal. And in the human body, metalloproteins are always produced in response to the presence of metallic ions such as silver, zinc, copper and others.

Now, here's the interesting part:

When using the ionic form of colloidal silver, the metalloprotein "escort" process starts immediately, because it's the silver ion that stimulates the body to produce metalloproteins in the first place.

But when using the metallic form of colloidal silver, the process is far more gradual due to the fact that it takes a while for the body to start converting metallic silver particles into silver ions, en masse.

his is why some clinical studies have demonstrated that it takes significantly longer for metallic silver to kill pathogens than it does for ionic silver.

The $64,000 Question

Finally, I ask you to put your thinking cap on for just a second and ask yourself this simple question:

If it were true that only elemental metals could survive the harsh acidic environment of the GI tract, and that ionic metals "can't last more than a few seconds in the body" as the so-called "true colloidal silver" people claim, then how does the human body absorb and utilize minerals from the food plants we eat, since they're all in the ionic form, and they all end up in the stomach in contact with stomach acid?

If the "true colloidal silver" people were correct in their assertions that ions can’t exist in the presence of stomach acid for "more than a few seconds", then it follows that human body could not absorb and utilize minerals from food plants at all, for the simple reason nature has those plants convert all minerals, including silver, to the ionic form.

That fact that our body does indeed absorb and utilize ionic minerals from plants is all of the evidence you need that the "true colloidal silver" people are being awfully disingenuous (to put it mildly) when they say ionic silver "can't work in the human body". 

Now please don't get me wrong, by any means. I'm not against the metallic form of colloidal silver or its metallic silver counterpart, nanosilver. I've documented in this report why both of them work, as well as how they work.

But I'm not going to deny the science behind colloidal silver just to make people feel better about their choices. And I'm not going to allow shifty marketers to get away with twisting the science all out of proportion to make one colloidal silver product sound superior to all others, when nothing could be further from the truth.

My advice to colloidal silver vendors is that they should allow their products compete in the open marketplace based upon their merits, and not upon "weird science" from their in-house labs that simply can't be backed up by valid and competent independent clinical research.

People will come back time-and-time again to purchase products that actually work. And if your colloidal silver product works, people will enthusiastically promote it for you, both online and among their own families and friends.

But if you lie to them about the science, then skepticism about all of your claims inevitably kicks in. And the old saying "Fool me once, shame on you. Fool me twice, shame on me," will eventually take its toll on your product sales as truth comes to light.

The Ion/Particle Debate

As long as we're still in learning mode, let's take this one step further.

It's important to note that some colloidal silver marketers, in an attempt to make their product appear superior, would lead you to believe that an ion is not a particle, and that therefore the ionic form of colloidal silver cannot really be considered "colloidal" in nature, because there are supposedly no "particles" in it.

This is ridiculous, of course. Just think it through for yourself. An ion is simply a particle of bare metallic silver that's missing an electron. That's it. Taking away an electron from a particle of silver does not change the fact that it's a particle of silver any more than taking away a person's big toe changes the fact the person is a human being. It's just a particle of silver missing an electron, i.e., an ionic particle.

 Simply put:

Metallic silver is composed of silver particles that are not missing an electron (and thus are biologically inactive/inert against pathogens).

And ionic silver is composed of silver particles that are missing an electron (which gives them a positive electrical charge and makes them biologically active against pathogens).

But don't just believe me. The International Union of Pure and Applied Chemistry defines an "ion" like this:

"An atomic or molecular particle having a net electric charge."

You can't get any simpler or more accurate than that.

The IUPAC is the recognized world authority in chemical terminology and nomenclature. It's even informally referred to as the "Gold Book", because it's considered to be the gold standard for scientific definitions. And its definitions are applicable to ALL fields of science.

Of course, you'll have some of these "true colloidal silver" people tell you "Yes, I know what the Gold Books says, but that definition doesn't apply to my product because it has special physical properties not covered in the Gold Book."

All I can say is in response to that little bit of silliness is please chuckle softly when they make that claim. Don't laugh too hard. Say something like "Well, bless your pointed little head", and avert your eyes as if you're embarrassed for them.

The IUPAC further states that colloid components include ionic particles. It even refers to the "colloidal ion".

So any colloidal silver marketer who would lead you to believe that an ion is not a particle and therefore cannot be part of a "true colloid" (or more accurately spoken, a true colloidal suspension) is either uninformed or attempting to deceive you with semantics.

To use the term "true colloidal silver", at least do so with the understanding that ionic colloidal silver is every bit as much "true colloidal silver" as the metallic form of colloidal silver claims to be.

In fact, ionic silver is even more so, because it's already in the biologically active, infection-fighting form, whereas metallic colloidal silver has to be converted inside the body into the biologically active, infection-fighting form in order to kill pathogens.

Again, they both work against pathogens. It's just that the metallic form works far more slowly inside the human body because it has to be converted to the biologically active, infection-fighting "specie" of silver (i.e., ionic silver) before it can be of any benefit whatsoever.

One Last Bit of Nonsense Debunked 

Finally, let me address one more piece of nonsense being promulgated by colloidal silver marketers. I know you're tired. You've had to take in quite a lot in this long article. So I'll be as brief as possible, I promise.

I'm talking about the people on the internet who claim that ionic silver is not effective inside the human body unless you first add a reducing agent to it, like powdered dextrose, in order to turn it into "true colloidal silver" (i.e., metallic silver) before drinking it.

This is where I lift my head to the sky and make a loud, disgusting pirate noise: Arrrggghhh!

Why in the world would anyone bother to convert ionic silver back into metallic silver before drinking it, knowing that your body is just going to have to convert it back to ionic silver for it to be effective against pathogens?

It's like saying, after you’ve prepared tomato soup for lunch that you have to convert it back to whole tomatoes before you can eat it. Or after you've boiled potatoes for dinner you have to convert them back to raw potatoes before eating them. There’s just no sense in it. It's a gimmick, pure and simple.

As I've stated over and over again:

Ionic silver is the biologically active, infection-fighting form of colloidal silver. If it's not ionic, it cannot kill pathogens.

Metallic silver is biologically inert. It has zero effect against pathogens in the human body, until it gets converted to ionic silver by shedding silver ions in the presence of acidic bodily fluids.

Every reputable clinical expert on silver acknowledges that fact. So repeat that to yourself over and over and over again until it's so ingrained in your brain that no one can ever dislodge it again with their ridiculous gimmicky ideas and silly notions.

If you've got ionic silver, you've got silver that's already in its active, infection-fighting form. If you convert it back to metallic silver from whence it came, your body will simply have to convert it back to ionic silver when you ingest it. So why not just ingest the ionic silver? Anything else is just plain stupid.

Look, there's plenty of money to be made in colloidal silver gimmickry. And there are plenty of people willing to part you from your hard-earned money with those gimmicks.

I'll just suffice it to say, there's no need on the face of God's green earth to convert your ionic colloidal silver to metallic colloidal silver. All you're doing is making it work slower in the body, because once you chemically convert it back to metallic silver and ingest it in its metallic form, it then has to be gradually converted back to ionic silver in the body order to be effective against pathogens.

 I've already explained that process numerous times throughout the course of this article. And I've demonstrated that the human body is designed to use silver (and all other minerals) in their ionic form rather than their elemental metal form. I've repeated it until I'm blue in the face, and the blue color is not because of argyria, it's because of exasperation with all of the nonsense being promulgated on the internet about colloidal silver.

I've even shown that the human body has a special transport mechanism for escorting silver ions through the harsh chemical environment of the gastrointestinal tract and into the bloodstream, tissues, organs and cells of the body where pathogens like to colonize.

So I'll suffice it to say this:

If someone tells you that you have to buy their magic pixie dust and add it to your ionic colloidal silver suspension in order to turn it into "true colloidal silver"... smile politely while hiding your wallet, and walk quickly away in the other direction. 

Okay. One last time, I'll summarize the facts for you. And then I'm done with this topic.

 

To Sum It Up: 

Although there are many forms of colloidal silver, you have two main forms vying for the spotlight today. They're the ionic form of colloidal silver and the metallic form (which is often erroneously referred to as "true colloidal silver").

The metallic form is largely composed of bare metal particles of elemental silver in a colloidal suspension. This form is also referred to as "nanosilver" when the metallic silver particles average less than 100 nm in size.

The ionic form is largely composed of tiny, electrically-charged atomic and molecular silver particles in a colloidal suspension. These are known as silver ions, and they're the same biologically active form of silver you'll find naturally in plants such as wheat and mushrooms.

All recognized scientific, clinical and medical research experts agree that the ionic form of silver is the biologically active, infection-fighting form, and that the metallic form only works against pathogens to the extent it's able to shed silver ions.

Both forms of colloidal silver – the ionic form and the metallic form – work against pathogens inside the human body. But the ionic form works because it's already in the biologically active, infection-fighting state, and the metallic form works only to the extent it's converted inside the human body to the ionic form.

Finally, the body has a built-in mechanism for escorting positively-charged silver ions through the harsh chemical environment of the stomach and into the cells, tissues and organs of the body where pathogens colonize. It's called the Metalloprotein Transport System, and without it no form of colloidal silver could possibly work inside the human body because all forms of colloidal silver are dependent upon silver ions to work against pathogens.

(And this is true for ALL metallic minerals in the body, not just silver. All metallic minerals must be converted into the ionic form so the Metalloprotein Transport System can protect them from the harsh chemical environment of the body and transport them into the organs, tissues and cells where they provide nutrition and perform other functions as well. This is why Mother Nature makes that conversion for us, for example, when plants absorb metallic or elemental minerals from the ground and convert them to the ionic form.)

All right. I've explained the science inside-out.

 And unlike the "true colloidal silver" people who base the majority of their claims on "research" conducted in their own in-house lab and which has never been confirmed through independent, unbiased research, in this report I've demonstrated through independent university-level clinical research conducted by unbiased researchers with no axes to grind that the ionic form of colloidal silver is hands-down the most effective form.

And why is the ionic form of colloidal silver the most effective form? It's because the silver ion is the active, infection-fighting "specie" of silver, whereas the metallic form of silver has no infection-fighting qualities whatsoever, except to the extent it sheds silver ions.

I've also amply demonstrated why the "true colloidal silver" people are full of bat stink with their spurious claims about ionic silver being rendered ineffective in the human body by "chloride ions" or "hydrochloric acid".

And I've explained why the body's Metalloprotein Transport System makes all of those silly claims moot since it's the system through which all metallic ions – including silver ions – are safely transported through the harsh chemical environment of the GI tract and into the blood, organs, tissues and cells of the body where pathogens colonize.

When using the ionic form of colloidal silver, the metalloprotein "escort" process starts immediately, because it's the silver ion that stimulates the body to produce metalloproteins in the first place.

But when using the metallic form of colloidal silver, the process is far more gradual due to the fact that it takes a while for the body to start converting metallic silver particles into silver ions, en masse.

Finally, I've explained that ionic silver works best against pathogens in the human body because, unlike metallic silver, it carries a positive electrical charge, while bacteria carry a negative electrical charge, causing silver ions to have a strong affinity for both gram negative and gram-positive bacteria. 

So if you've absorbed the above information with even a moderate degree of understanding, you can feel confident that you now understand more about colloidal silver than 99% of people, including most of the self-appointed online "experts".

Yours for the safe, sane and responsible use of colloidal silver,

Steve Barwick

Steve Barwick, author

The Ultimate Colloidal Silver Manual"

 

For silver ions to be in a solution, water would have to dissolve a silver compound. Silver fluoride, silver acetate, and silver nitrate, form ionic solutions of silver ions (and the other non metallic component) are among the few silver compounds which will dissolve in water, the rest are insoluble or of such low solubility to be considered as insoluble. And since the silver rod does not dissolve instantly into silver ions as a solution, similar to salt or sugar in water, the claim that silver ions are solutions or not colloids is an error of epic proportions.

Colloidal silver generators produce colloidal silver composed of circa 85-95% suspended silver ions (charged particles) as colloidal electrolytes and the balance as suspended silver particles, both dispersed in water..

Colloid: A noncrystalline (smaller than a colloid, typically components of solutions, my addition in parenthesis) substance consisting of large molecules or ultramicroscopic particles of one substance dispersed through a second substance.

Colloids include gels, latex, aerosols, and emulsions. The particles do not settle and cannot be separated out by ordinary filtering or centrifuging like those in a suspension (liquids), but can be removed by dialysis a process of separating molecules in a liquid by the difference in their rates of diffusion through a semipermeable membrane, such as dialysis tubing or as when originally discovered through parchment paper.

 The term colloid refers to suspended particles (arbitrarily) in a size range between 1 nanometer (0.001 microns) and 1000 nanometers (1 micron) in a dispersing agent in a dual phase mixture. The suspended particle and dispersing agent have no material restrictions (solid, gas, liquid), except that all gases are soluble in all solutions including other gasses. The air you breath is a gaseous solution.

In short, a colloid is a dual phase mixture which contains suspended material(s) in a dispersing agent in a specific size range.

By contrast, a solution is formed when a solvent (such as water) dissolves (disassociates the ion bonds of) a material (called a solute) in to a homogenous, single phase mixture, down to the atomic level. 

A liquid colloid (hydrosol, hydrophobic, not easily mixed into colloidal suspension in water) differs from a solution:

A liquid colloid (sol) does scatter light (Tyndall beam).

A liquid colloid (hydrophobic sol, category for colloidal silver) is thermodynamically unstable (cold will cause the colloidal particles to precipitate).

A liquid colloid's suspended particles can be removed through filtration (dialysis), but not by mechanical filtration.

A liquid colloid (hydrophobic sol) cannot reform once the colloidal system is broken (all particles precipitated).

A liquid colloid does not reach a saturation point

A liquid colloid does not affect the freezing or boiling point

The presence of the colloidal material does not affect the freezing or boiling point of the liquid.

By comparison:

A solution differs from a colloid:

Characteristics of a solution:

A solution is a homogeneous mixture down to the atomic level.

The solution does not allow a beam of light to scatter.

A solution is stable.

The solute cannot be separated from the solution by mechanical filtration or by dialysis.

Remove the solvent from the solution (for example evaporate the water or boil away the water) the dissolved solute returns to its dry state as a compound molecule. Add the solvent again, and the solute returns to solution.

A solution reaches a saturation point in which no further solute can be added. Add too much sugar or salt to a glass of water, and a solid will form at the bottom of the jar at the same rate as the solute is dissolved back into solution.

A solution alters the boiling and freezing point of the solvent. (Example a salt solution (sea water) freezes at 0 F compared to 32 F for distilled water. Seawater has no reliable numbers for boiling points as the salinity varies from the Mediterranean (highest concentration) to other continental areas (larger influx of fresh water from major rivers.

 As to colloids and Tyndall (Faraday-Tyndall):

The 19th Century Irish scientist John Tyndall was born on August 2, 1820 in Leighlinbridge, Ireland. He studied the Tyndall Effect in 1869.

The Tyndall Effect is the effect of light scattering in many directions in colloidal dispersion, while showing no light in a true solution. This effect is used to determine whether a mixture is a true solution or a colloid. "To be classified colloidal, a material must have one or more of its dimensions (length, width, or thickness) in the approximate range of 1-1000 nm." (The term approximate, deals with the now accepted discovery of colloids which are smaller than 1 nanometer).

Because a colloidal solution or substance (like fog) is made up of scattered particles (like dust and water in air), light cannot travel straight through. Rather, it collides with these micro-particles and scatters causing the effect of a visible light beam. This effect was observed and described by John Tyndall as the Tyndall Effect.

The Tyndall effect is an easy way of determining whether a mixture is colloidal or not. When light is shined through a true solution, the light passes cleanly through the solution, however when light is passed through a colloidal solution, the substance in the dispersed phases scatters the light in all directions, making it readily seen.

A Tyndall effect (sometimes called the Faraday-Tyndall Phenomenon) is one of the test used to determine colloids. 

What do clouds and fog, Styrofoam, opals, brass, cranberry glass, ink, paint, homogenized milk, emulsified cod liver oil, cold cream, latex, whipped cream, washing with soap and water (micelle), mayonnaise, pumice stones, foam rubber, cheese, butter, shoe polish, cigarette smoke (liquid particles suspend in a gas) and pearls have in common? Yes, these are all colloids. All but one of the above does not contain metal(s) as a component, for example, opals consist of silicon dioxide and water.

The claim "only metallic particles are colloids and silver ions are not colloids (but solutions)" is promoted on the internet by a company to sell their colloidal silver bottles. Utopia Silver has taken a page from Purest Colloids, Inc.

Back to Solutions. A solution consists of a solvent (water, acids, alcohols, ect) which dissolves a solute (mineral compounds, metal, inorganic chemical compound) by disassociation of the ionic bounds between chemical compounds to form a single phase (uniformly indistinguishable to the atomic) homogeneous. This is the definition which applies to our discussion. (Sugar and other carbohydrates dissolve in another manner. Sugar is a polar molecule. The positive side of the sugar attracts the negative side of the water. Conversely, the negative side of the sugar attracts the positive side of the water. The sugar-water interaction is stronger than the sugar-sugar interaction, so the sugar dissolves into solution.).

 The term solution has many definitions other than the precise scientific one, and solution is used interchangeably with liquid which adds to the confusion. I have read the term colloidal solutions in very respected science texts. By definition solution and a colloid are mutually exclusive.

As I mentioned earlier, silver nitrate, silver fluoride, and silver acetate are the three silver compounds that dissolve in water to form a solution of silver ions and its other component (in ionic form). Almost the other silver compounds of such extremely low solubility in water as to be considered insoluble and thus do not form solutions. Another name for silver compounds are silver salts or silver acid salts as chemically appropriate.

As metallic silver does not readily dissociate its metallic bounds when stirred in water to form metallic silver and/or silver ions, we can easily see that singular silver ion solutions as such do not exist. And as this form of colloid does not readily form colloidal silver, colloidal silver is hydrophobic.

Since we are on the subject, the "true colloidal silver" people state you can spot ionic silver because it's clear and colorless. Similarly, they tout their products presence of color.

A competitor of Purest Colloids, Inc., Natural Immunogenics, sent a sample of MesoSilver to the University of Miami School of Medicine Department of Cell Biology and Anatomy to have MesoSilver's particle diameter claim of 0.67 nanometers 11 years agos. The competitor of MesoSilver contacted the US Department of Commerce's National Institute of Standards and Technology (NIST) as to the proper test. The NIST reply was to use TEM which was then and now the forensic standard. Which the U of M used. (And yes you can take TEM photographs before all the water has boiled away in the vacuum of the electron Microscope). 

http://www.nist.gov/mml/mmsd/ silver-051011.cfm

http://www.hydrosolinfo.com/ articles/silver-2004-12-16.php

Methodology for Determining Particle Size

Natural-Immunogenics Corp. actually consulted the National Institute of Standards & Technology (“NIST”) concerning the use of Laser Photon Back Scattering Spectrophotometry, and in particular the Malvern HPPS instrument of that type (which at the time CSL used)– which we were told NIST was currently evaluating in house. In an exchange of email with Dr. Ajit Jilla of NIST, it appears they had already concluded that such instruments, as the HPPS specifically, are unreliable in the analysis of [colloidal] materials in the one nm range of Sovereign Silver™. 

The TEM (Transmission Electron Microscope) was one of two instruments recommended by NIST as being capable of measuring these and other sub-nanometer particles. This Company has employed a Phillips EM-400T for such purposes since 1999. Its specifications assure the researcher that it is capable of resolution to less than 3 Angstroms (0.3nm).

A number of ‘colloidal silver’ specimens examined by Natural-Immunogenics™ over the years, such as its own product as well as Mesosilver, Silver Biotics etc., were recently submitted to the electron microscopy laboratory at the University of Miami Medical School. Not only did the results corroborate work done by the company over the years, as will be seen in the next section, it also laid the basis for doing much more third party work to strengthen the claims made by the Company. 

Actual Particle Size and Character 

Natural-Immunogenics™ has been evaluating products of its own manufacture for quality control and for its own research, as well as to collect data on all such products as are available in the marketplace today. A large number – almost 100 – have been examined to date.

Here we will submit micrographic examinations both by the Company and by the lab at the University of Miami Medical School. You will note that not only does characterization remain consistent, but the size measurements do as well.

 The first two figures are of Mesosilver, from TEM analyses done by the Company over a period of several years. The third was done at the University of Miami Medical School. Although the character of that formulation continues to be consistent, the data derived is significantly different from that claimed by the manufacturer of Mesosilver for its product.

Figure 1 Mesosilver™ (NIC) Sep '01 100kx

Figure 2 Mesosilver™ (NIC) Aug '03-100kx

When observed in comparative micrographs - same preparation, same magnification - the particles of Sovereign Silver™ bear little relationship to those of Mesosilver either in size or character. Actually, were Mesosilver's claim for its particle size correct at its claimed 0.65 nm, then, proportionately, those of Sovereign Silver™ would be sub-atomic -- and that is just not possible!

The much larger particles and flocculates that comprise the Mesosilver product are, in fact, the reason for its dark tea color. Such simple criteria cannot be dismissed just because the manufacturer 'does not want to go there'....

Now look at Natural-Immunogenics™' Comparative Analysis and then at The Certificates of Analysis from the University of Miami. In them you will see the size analyses for both products as well as a micrograph and Certificate for Sovereign Silver, also done at U M. Now contrast Mesosilver™ with Sovereign Silver™. Nothing more needs be said.

Figure 3 Mesosilver (U M) May '04-100kx

The above might be a reason to discredit the TEM image, as the report contradicts the 0.67 nm claim; 5.5 nm..."most were considerably larger than this ranging up to 450 nanometers." Diameters larger than 200 nm produce color in colloidal silver 10 ppm in visible light. mostly larger particles ranging up to 450 Nanometers would be in this range. MesoSilver is claimed to produced by a proprietary process; the consensus amongst the industry, HVAC similar to the method used by Utopia Silver (HVAC).

Colloidal silver end products produced by HVAC result in very large particles at 20 ppm. Most commercial products sold as colloidal silver are produced by HVAC as the throughput (how much produced in the shortest amount of time) favors HVAC, a gallon or more in 10 minutes time. Time is money in manufacturing. By contrast, low voltage DC units produce a quart in 3 hours time, impractical for a supplement company, but for home use this produces the smallest silver diameters.

Utopia Colloidal Silver uses HVAC, https://www.utopiasilver.com/ product/colloidal-silver- advanced-8-oz-bottle/ 

"Product Description 

Colloidal Silver Facts

Advanced Colloidal Silver is a mineral suspension produced at about 20 ppm of .9999 pure silver in de-ionized water. It is a mineral supplement used to boost and augment the body’s immune system. The silver content is comprised of approximately 15-20% ionic silver and 80-85% particle silver. Both ionic silver and non-ionic/particle silver have their own advantages and both are effective at killing one-celled organism

 

Note: Advanced Colloidal Silver (particle silver) has color because particles reflect light and therefore show a dark brownish w/ greenish undertone color. Ionic Silver is clear because ions do not reflect light. " 

I have spoken to my share of do-it-yourself colloidal silver generator builders who used 9 Volt battery chargers (with 37-75 times the current of the Micro Particle Generator, too high for small particle production), and a pair of silver wires, and distilled water, who said, "Oh my generator produces true colloidal (metallic) silver, its a beautiful yellow color!" I asked how they determine their concentrations generated. "With a TDS meter." They don't believe when I tell them metallic silver is non-conductive, only silver ions would give a measurement. "But, it produces a Tyndall," they counter. So does any of my generators which produce clear colloidal silver, a definite Tyndall. "But, the clear stuff is a solution," they retort. Well, did you ever hear of Orr and Dallavalle? "Is that a music group?" No, they're two scientists who published on the presence of color in colloidal silver back in 1959

Clyde Orr and J. M. Dallavalle wrote 56 years ago in Fine Particle Measurement Size, Surface, and Pore Volume on colloidal silver in visible light. The authors stated colloidal silver at 10 ppm exhibited a yellow color if the particle size was larger than 0.2 microns (0.2 micrometers more commonly referred to presently as 200 nanometers) and was otherwise clear if smaller than this diameter.

The late Professor Ronald Gibbs director of the Center for Colloidal Science at the University of Delaware between 1981-2000 cited Orr and Dallavalle's work in his 1999 book, Silver Colloids---Do They Work? Professor Gibbs wrote that the highest quality colloidal silver is clear; Gibbs only tested metallic silver and eliminated any ionic silver products from his test of 15 over the counter colloidal silver products. Gibbs also wrote that colloidal silver could be yellow if flocculation had occur (found in poor quality colloids), or if contamination had occurred (the addition of food coloring). All 4 of his of Gibbs 4 Star colloidal silver was metallic particles and clear.

Fine Particle Measurement. Size, Surface, and Pore Volume by Clyde Orr, Jr. and J. M. Dallavalle, Macmillan Company (1959) Clyde Orr, Jr. PhD was a well regarded scientist and a pioneer in how to measure the total area of all the tiny surfaces. http://www.ajc.com/news/news/ local/dr-clyde-orr-88-co- founded-gwinnetts-first-high- te/nQkNX

No colloidal silver products of any form (colloidal electrolyte or metallic particulate) was available for sale in Health Food Stores until the 1990's.

The HVAC colloidal silver that Utopia produces must contain particles that are larger than 200 nm which would account for the color. Flocculation/aggregation from poorly dispersed silver particles could additionally account for the dark brown color. The MesoSilver (tested by the U of M) writes in their sales literature that their product has an Ice Tea color.

From an earlier email from another true colloidal silver and silver ions are colloids, email who had educated himself, using the term loosely, and the http://www.silver-colloids.com/ website:

" I also like the fact that they don't sell anything."

 Well, the website www.silver-colloids.com must sell MesoSilver to afford the Pay per Click Advertising. I paid a professional SEO (search engine optimization) company to disclose how much money the Pay Per Ads at the top of Google Searches cost. The company could only give information for that day: $3,334.00 USD!!!!! If the amount was typical (this was in an off season, in May of 2015) their advertising bill to Google would be over $1 million annually. The organic traffic (search engine generated) to the website would only be worth $500.00 per month to charge advertisers. Something must pay that Google bill, or sales generated from that pseudo information website.

 

Statements on the website in "quotations" and my commentary in (parenthesis). 

"Colloidal Silver Generators- There are dozens if not hundreds of products on the market advertised as being colloidal silver generators."

(A hyperbole, more likely the count is closer to one hundred.)

"Such products can be high or low voltage AC or DC and all operate by electrolysis to produce mostly silver ions and some silver nanoparticles."

(Correct as to DC generators which produce by electrolysis (Faraday's Principle). Incorrect as to low voltage AC generators, zero on the market, and the only individual DIY low voltage AC generator according to the inventor didn't work; he converted it to DC. Omitted was two companies that two companies sell HVAC "generators" which produce primarily metal particulate silver with the balance as silver ions similar to MesoSilver and Utopia Silver.)

"The ionic silver solutions produced by these generators are no less effective than the best commercial ionic silver products."

(Quite true.)

"If you believe the marketing hype for ionic silver from the companies on this list there is no reason that you would not want to consider using a home colloidal silver generator and save a lot of money."

(Also quite true as to saving money.) 

"While the effectiveness of ionic silver is far less than a true colloidal silver product, if you are satisfied with the results obtained from using ionic silver there is no need to pay high prices for one of the commercial products when you make virtually the same thing at home for pennies."

(Here Frank Key is in the minority opinion, Ionic silver is acknowledge to be superior in efficacy (300% more effective) than metallic silver (his made up term, "true colloidal") see studies at http://thesilveredge.com/ studies.shtml#.Vk1qHL9z8_A

However Mr. Key is correct that "there is no need to pay high prices for one of the commercial products when you make virtually the same thing at home for pennies." His product for about a quart (two 500 ml bottles would be 33.8 fl oz) would set you back $99.74 without shipping or if purchased at a Health Store without sales tax.)

"Of course the commercial producers will try to wow you with their techno-babble nonsense to convince you that their products are superior."

(Mr. Key is guilty of the pot calling the kettle black.)

"Many commercial ionic silver products are produced using colloidal silver generators that are sold for home use." 

(Totally incorrect, no commercial manufacturer could afford stay in business if they produced with home colloidal silver generators. They have to produce in bulk, quickly (HVAC) or the process for Silver Biotics which uses High Voltage 25,000 AC a large 100 gallon tank, an air bubbler stirrer (as of 2006 when the company switched from a mechanical stirrer), Hydrogen Peroxide additions and 24 hours time.

And these companies must follow Current Good Manufacturing Practice regulations (cGMP) enforced by the US Food and Drug Administration which is expensive and would necessitate high production quantities in the shortest period of time that is feasible.)

"Based on the information they provide, they claim that the generator I purchased from you only produces "Ionic Silver" and not Colloidal Silver or Nano-Particle Colloidal Silver."

And now for my ace up my sleeve, which I pull on people such as your customer, who ask, does your generator produce colloidal silver or ionic silver.

Would you doubt Harvard's Physics Department on the silver ions produced by DC electrolysis is colloidal silver.

http://www.physics.harvard. edu/~wilson/arsenic/ remediation/Silver%20Ceramic/ CS.html 

"The present success of the CS (Colloidal Silver) generator is largely attributable to the high quality of the new electrical unit, which converts 240AC to 24DC. What is indicated here is a simple cost analysis of producing this kind of CS.

 The concentrated CS generator shown on the home page is currently utilizing two flasks, of 2.4 liters each. However additional flasks can be wired into the system, up to eight in all. Given that each flask contains about 500 ppm of CS, this will saturate sixteen candles. So, 8 flasks x 16 candles per flask =128 candles, the daily production of concentrated CS.

Several people have asked whether the flask size can be increased, so as to get bigger volumes of CS, and in my view this may be tricky. For example, if the flask size is doubled then the wet surface area of electrodes must be increased, quite clearly. And the DC voltage would also need to be increased. But at what DC voltage would the system require safety apparatus? While we feel confident that the 24 volts DC for the generator is perfectly safe, at additional voltage would tend toward an unsafe system. Would a 4.8 liter flask require double the voltage, something like 48 volts DC? And would this require the enclosure of the leads to the circuit, so as to avoid a shock to the operator?

Post Script of 23 April: If the producers are purchasing the concentrated colloidal silver, for saturation of their filters, then this should be carefully sourced. It may be considered best to know the form of the silver, resulting within the filter, in case further studies on these are at some point considered desirable. In general, however, silver is considered to be among the most benign of substances, no harmful health effects associated." 

One of the world recognized leading institutions of higher learning states that their low voltage DC generator produces colloidal silver. The physics department has a reputation to project and protect wouldn't make such an egregious error as on the subject of colloidal silver.

(As to comments why Prof. Gibbs wrote contrary to the Ice Tea vs Gibbs, the highest quality colloidal silver (when he was only testing metallic silver) 

http://www.silver-colloids. com/Authors/key.html

"Mr.Key was instrumental in getting Prof. Ronald Gibbs interested in doing research on colloidal silver after he visited the Colloidal Science Laboratory and observed some early experiments being conducted by Mr. Key in the mid 1990's. For several years thereafter, Mr. Key and Prof. Gibbs collaborated on research of silver colloids. Mr. Key designed and built much of the equipment that was used by Prof. Gibbs at his university laboratory to conduct the research that resulted in the booklet "Silver Colloids" that is available for free download on this web site. Prof. Gibbs was the Chairman of the Colloidal Science Department at the University of Delaware until his untimely death in May, 2000"

and

"http://www.silver-colloids. com/Pubs/pubs.html"

"Frequently asked question: Dr. Ronald Gibbs booklet states that high-quality Colloidal Silver is colorless, but the highest particle surface area colloid in the tabulations is dark in color, why this discrepancy? 

The material in Ron Gibbs book is slightly dated. Ron died in May 2000 and the book material was frozen about a year before. For example, the samples that Ron tested, some of which were made for him in the Colloidal Science Lab. Inc.(CSL) were believed by Ron to be at least 50% colloidal when in fact they were mostly ionic (typically 90%). The methods developed at CSL to determine ionic vs. particle concentration were just being developed at the time Ron wrote the book and so he was not fully informed about the ion/particle ratio of the test samples and consequently made some erroneous assumptions. Ron assumed the sample were at least 50% particles when they were only 10%. This erroneous assumption caused Ron to believe that he was testing colloidal silver when in fact he was testing ionic silver (90%). Ron fully intended to correct this error in subsequent publications but succumbed to pancreatic cancer before being able to publish the correction.

While this error in the booklet has been known for years it has not stopped companies that sell ionic silver labeled as Colloidal Silver from misleading the buying public with statements such as Professor Ronald J Gibbs informs us that all of the highest quality colloidal silver products are colorless.

Since true colloids of high particle concentration had not yet been developed when Ron wrote the booklet, all products of that time which displayed color were the result of large silver particles present in ionic solutions that were produced using electrolysis methods. Those products contained about 10% of the silver content in the form of particles. For a solution to display color while containing such a relatively small amount of particles requires that the particles be quite large (typically 100 - 500 nm).

True silver colloids that have a high percentage of the silver content in the form of nanometer sized particles will absorb visible light causing the apparent color to appear dark-amber or brown. It is the very high concentration of particles, not large particle size or contamination, that gives these products such color"

I have attached a copy for Professor Ronald Gibbs book. When you read through the book, please note the manufacturers name of the laboratory equipment on page 38 (Zeiss of West Germany, including the TEM used, and if there was any acknowledgement of Mr Frank Keys help or thanks for his assistance. The book states a sample of 15 unnamed brands of commercial colloidal silver were tested, nowhere is there mention of samples being produced and supplied by the CSL.

To a reasonable person would a professor and director of the center of colloidal science at the University of Delaware since 1981, who's work include published 85 peer review journal articles (professional papers) 5 technical journals, edited 14 books, 61 lectures on testing colloidal materials, and went out of his way to eliminate silver ion containing samples in his book wouldn't know the difference between 50% or 10% metallic content?

 

Any questions?